DRPM: An advanced predictive model for early diabetes detection and risk stratification.

Journal: Molecular therapy. Nucleic acids
Published Date: May 27, 2025

Abstract

Diabetes is a prevalent chronic disease that poses a significant burden on individuals and healthcare systems. Early diagnosis and effective management are essential for delaying disease onset and minimizing complications. In this study, we developed a deep learning-based risk prediction model using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2011 to 2018. From an initial set of 36 variables, and through feature selection, five key features were identified through feature selection techniques to construct the model. The model demonstrated robust performance, accurately predicting diabetes risk with high precision in test data. External validation further confirmed its ability to correctly identify individuals at risk of developing diabetes. To enhance its practical application, we implemented a risk stratification system and developed a user-friendly online tool, available at http://cbcb.cdutcm.edu.cn/drpm/, allowing easy access for users. This model provides a valuable tool for diabetes risk screening and personalized early detection.

Authors

  • Fulei Nie
    Center of Bioinformatics (COBI), Key Laboratory for NeuroInformation of Ministry of Education, University of Electronic Science and Technology of China, Chengdu 610054, China.
  • Xiaoming Song
    School of Life Sciences, North China University of Science and Technology, Tangshan 063210, China.
  • Wei Chen
    Department of Urology, Zigong Fourth People's Hospital, Sichuan, China.

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