Neuropsychological and clinical variables associated with cognitive trajectories in patients with Alzheimer's disease.

Journal: Frontiers in aging neuroscience
Published Date: May 27, 2025

Abstract

BACKGROUND: The NeuroArtP3 (NET-2018-12366666) is a multicenter study funded by the Italian Ministry of Health. The aim of the project is to identify the prognostic trajectories of Alzheimer's disease (AD) through the application of artificial intelligence (AI). Only a few AI studies investigated the clinical variables associated with cognitive worsening in AD. We used Mini Mental State Examination (MMSE) scores as outcome to identify the factors associated with cognitive decline at follow up.

Authors

  • Marianna Riello
    Azienda Provinciale per i Servizi Sanitari (APSS) di Trento, Trento, Italy.
  • Monica Moroni
    Fondazione Bruno Kessler Research Center, Trento, Italy.
  • Stefano Bovo
    Fondazione Bruno Kessler, Trento, Italy.
  • Flavio Ragni
    Fondazione Bruno Kessler, Trento, Italy.
  • Manuela Buganza
    Neurology Unit, Provincial Health Services of Trento, Trento, Italy.
  • Raffaella Di Giacopo
    Azienda Provinciale per i Servizi Sanitari (APSS) di Trento, Trento, Italy.
  • Marco Chierici
    a Fondazione Bruno Kessler , Trento , Italy.
  • Lorenzo Gios
    TrentinoSalute4.0 -Competence Center for Digital Health of the Province of Trento, Trento, Italy.
  • Matteo Pardini
    Department of Neuroscience (DINOGMI), University of Genoa and Neurology Clinics, Polyclinic San Martino Hospital, Genoa, Italy.
  • Federico Massa
    Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.
  • Monica Dallabona
    Unità Operativa Psicologia, Dipartimento Transmurale Salute Mentale, Azienda Provinciale per i Servizi Sanitari, Viale Verona, Trento, 38123, Italy.
  • Elisa Vanzetta
    Department of Mental Health, Division of Psychology, Provincial Health Services of Trento, Trento, Italy.
  • Cristina Campi
    IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Michele Piana
    IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Sara Garbarino
    IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Manuela Marenco
    IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Venet Osmani
    Fondazione Bruno Kessler Research Institute, Trento, Italy.
  • Giuseppe Jurman
    a Fondazione Bruno Kessler , Trento , Italy.
  • Antonio Uccelli
    IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
  • Bruno Giometto
    Centro Interdipartimentale di Scienze Mediche (CISMed), Facoltà di Medicina e Chirurgia, Università di Trento, Trento, Italy.

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