The Identification of Novel Prognostic and Predictive Biomarkers in Breast Cancer via the Elucidation of Tumor Ecotypes Using Ecotyper.

Journal: Cancer innovation
Published Date: May 27, 2025

Abstract

BACKGROUND: Breast cancer is a highly heterogeneous disease, characterized by tumor and nontumor cells at various cell states. Ecotyper is an innovative machine learning framework that quantifies the tumor microenvironment and delineates the tumor ecosystem, demonstrating clinical significance. However, further validation is needed in breast cancer.

Authors

  • Feng Du
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), The VIPII Gastrointestinal Cancer Division of Medical Department Peking University Cancer Hospital and Institute Beijing China.
  • Jie Ju
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Day Care Peking University Cancer Hospital and Institute Beijing China.
  • Fangchao Zheng
    Department of Medical Oncology, Cancer Research Center, Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan Shandong Province China.
  • Songlin Gao
    Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), The VIPII Gastrointestinal Cancer Division of Medical Department Peking University Cancer Hospital and Institute Beijing China.
  • Peng Yuan
    Surgical Planning Laboratory, Department of Oral and Maxillofacial Surgery, Houston Methodist Research Institute, Houston, TX 77030, USA.

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