A Clinically Annotated Transcriptomic Atlas of Nervous System Tumors.

Journal: Neuro-oncology
Published Date: May 27, 2025

Abstract

BACKGROUND: While DNA methylation signatures are distinct across nervous system neoplasms, it has not been comprehensively demonstrated whether transcriptomic signatures exhibit similar uniqueness. Additionally, no large-scale dataset for comparative gene expression analyses exists. This study addresses these knowledge and resource gaps.

Authors

  • Chi H Le
    School of Medicine, Vanderbilt University, Nashville, TN USA.
  • Ajai K Nelson
    Oberlin College, Oberlin, OH, USA.
  • Adam J Berrones
    Division of Prevention and Quality Improvement, Kentucky Department for Public Health, Frankfort, KY, USA.
  • Janki R Naidugari
    School of Medicine, University of Louisville, Louisville, KY, USA.
  • Robert P Naftel
    Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Eyas M Hattab
    Department of Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY, USA.
  • Brian J Williams
    Department of Neurological Surgery, University of Louisville, Louisville, KY, USA.
  • Akshitkumar M Mistry
    Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN.

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