Predicting rTMS treatment response in depression: use of machine learning models to identify the roles of metabolic and clinical factors.

Journal: Journal of affective disorders
Published Date: May 28, 2025

Abstract

BACKGROUND: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression in patients with major depressive disorder (MDD) and bipolar disorder (BD), but accurate prediction of treatment response remains a challenge. This study aims to identify key metabolic and clinical factors that serve as predictors of rTMS efficacy in patients with MDD and BD.

Authors

  • I-Chun Liu
    Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Po-I Wu
    Department of Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Van San Bui
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Psychiatry, Hanoi Medical University, Hanoi, Viet Nam; National Institute of Mental Health, Bach Mai Hospital, Hanoi, Viet Nam.
  • Tsung-Hua Lu
    Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Huai-Hsuan Tseng
    Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Sheng-Hsiang Lin
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
  • Po See Chen
    Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: chenps@mail.ncku.edu.tw.

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