Evaluation of vascular cognitive impairment and identification of imaging markers using machine learning: a multimodal MRI study.

Journal: Frontiers in neurology
Published Date: May 29, 2025

Abstract

BACKGROUND: Vascular cognitive impairment (VCI) is prevalent but underdiagnosed due to its heterogeneous nature and the lack of reliable diagnostic tools. Machine learning (ML) enhances disease evaluation by enabling accurate prediction and early detection from complex data. This study aimed to develop ML models to detect VCI using clinical data and multimodal MRI, and to explore the associations between imaging markers and cognitive function.

Authors

  • Haoying He
    Department of Neurology, Zhongnan Hospital of Wuhan University, 169# East Lake Road, Wuchang District, Wuhan 430071, China.
  • Dongwei Lu
    Department of Neuropsychology, Zhongnan Hospital of Wuhan University, 169# East Lake Road, Wuchang District, Wuhan 430071, China. Electronic address: 2008302180101@whu.edu.cn.
  • Sisi Peng
    Department of Neuropsychology, Zhongnan Hospital of Wuhan University, 169# East Lake Road, Wuchang District, Wuhan 430071, China.
  • Jiu Jiang
    Electronic Information School, Wuhan University, Wuhan 430072, China.
  • Fan Fan
    Key Laboratory of the Ministry of Education for Optoelectronic Measurement Technology and Instrument, Beijing Information Science and Technology University, Beijing, China.
  • Dong Sun
    Department of Mechanical and Biomedical Engineering, City University of Hong Kong, Hong Kong 999077, China. medsun@cityu.edu.hk.
  • Tianqi Sun
    Department of Neurology, Zhongnan Hospital of Wuhan University, 169# East Lake Road, Wuchang District, Wuhan 430071, China.
  • Zhipeng Xu
    Institute of Photoelectronic Thin Film Devices and Technology, Nankai University, Tianjin, 300350, P. R. China.
  • Ping Zhang
    Department of Computer Science and Engineering, The Ohio State University, USA.
  • Xiaoxiang Peng
    Department of Neurology, Third People's Hospital of Hubei Province, Wuhan, China.
  • Ming Lei
    Department of Radiology, Zhuhai Hospital, Guangdong Provincial Hospital of Traditional Chinese Medicine, 53 Jingle Road, Zhuhai City, Guangdong Province, China.
  • Junjian Zhang
    Department of Neurology, Zhongnan Hospital of Wuhan University, 169# East Lake Road, Wuchang District, Wuhan 430071, China. Electronic address: zhangjj@whu.edu.cn.

Keywords

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