Genome-wide Association Studies of the Pathogenic Sphingosine-1-Phosphate Gene in Ulcerative Colitis.

Journal: Endocrine, metabolic & immune disorders drug targets
Published Date: May 29, 2025

Abstract

BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease that can lead to malignancies over time. Sphingosine-1-phosphate (S1P) receptor signaling affects lymphocyte trafficking and vascular integrity, influencing intestinal inflammation. This study aimed to identify S1P-related key genes in UC.

Authors

  • Hongyu Chen
    Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, 410081, China.
  • Jingyu Shang
    Department of Gastroenterology, Afffliated Hospital of Nanjing University of Chinese Medicine (JiangSu Province Hospital of Chinese Medicine), Nanjing, China.
  • Song Zhao
    Department of Gastroenterology, Afffliated Hospital of Nanjing University of Chinese Medicine (JiangSu Province Hospital of Chinese Medicine), Nanjing, China.
  • Luzhou Xu
    Department of Gastroenterology, Afffliated Hospital of Nanjing University of Chinese Medicine (JiangSu Province Hospital of Chinese Medicine), Nanjing, China.
  • Hong Shen

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals