CT-Based Radiomics for Predicting PD-L1 Expression in Non-small Cell Lung Cancer: A Systematic Review and Meta-analysis.

Journal: Academic radiology
Published Date: May 29, 2025

Abstract

BACKGROUND AND PURPOSE: The efficacy of immunotherapy in non-small cell lung cancer (NSCLC) is intricately associated with baseline PD-L1 expression rates. The standard method for measuring PD-L1 is immunohistochemistry, which is invasive and may not capture tumor heterogeneity. The primary aim of the current study is to assess whether CT-based radiomics models can accurately predict PD-L1 expression status in NSCLC and evaluate their quality and potential gaps in their design.

Authors

  • Mohsen Salimi
    Research Center of Thoracic Oncology (RCTO), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Pouria Vadipour
    Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI, USA.
  • Adnan Khosravi
    Research Center of Thoracic Oncology (RCTO), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran (M.S., A.K., B.S., M.M., P.R., S.S.).
  • Babak Salimi
    Research Center of Thoracic Oncology (RCTO), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran (M.S., A.K., B.S., M.M., P.R., S.S.).
  • Maryam Mabani
    Research Center of Thoracic Oncology (RCTO), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran (M.S., A.K., B.S., M.M., P.R., S.S.).
  • Parsa Rostami
    Research Center of Thoracic Oncology (RCTO), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran (M.S., A.K., B.S., M.M., P.R., S.S.).
  • Sharareh Seifi
    Research Center of Thoracic Oncology (RCTO), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: sh_seifi@yahoo.com.

Keywords

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