Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorder.

Journal: EBioMedicine
Published Date:

Abstract

BACKGROUND: Synucleinopathies include a spectrum of disorders varying in features and severity, including idiopathic/isolated REM sleep behaviour disorder (iRBD), Parkinson's disease (PD), and dementia with Lewy bodies (DLB). Distinct brain atrophy patterns may already be seen in iRBD; however, how brain atrophy begins and progresses remains unclear.

Authors

  • Stephen Joza
    The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, H3A 2B4, Canada; Division of Neurology, Department of Medicine, and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Canada.
  • Aline Delva
    The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, H3A 2B4, Canada.
  • Christina Tremblay
    The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, H3A 2B4, Canada; Centre for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Cœur de Montréal, Montreal, H4J 1C5, Canada.
  • Andrew Vo
    The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, H3A 2B4, Canada.
  • Marie Filiatrault
    Centre for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Cœur de Montréal, Montreal, H4J 1C5, Canada.
  • Max Tweedale
    The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, H3A 2B4, Canada.
  • Jean-François Gagnon
    Centre for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Cœur de Montréal, Montreal, H4J 1C5, Canada; Department of Psychology, Université du Québec à Montréal, Montreal, H2X 3P2, Canada; Research Centre, Institut universitaire de gériatrie de Montréal, Montreal, H3W 1W5, Canada.
  • Ronald B Postuma
    The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, H3A 2B4, Canada; Centre for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Cœur de Montréal, Montreal, H4J 1C5, Canada; Department of Neurology, Montreal General Hospital, Montreal, H3G 1A4, Canada.
  • Alain Dagher
    The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, H3A 2B4, Canada.
  • Johannes Klein
    Oxford Parkinson's Disease Centre and Division of Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Michele Hu
    Oxford Parkinson's Disease Centre and Division of Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
  • Petr Dusek
    Department of Neurology, 1st Faculty of Medicine, Centre of Clinical Neuroscience, General University Hospital in Prague, Charles University, Prague, Czechia.
  • Stanislav Marecek
    Department of Neurology and Centre of Clinical Neurosciences, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czechia.
  • Zsoka Varga
    Department of Neurology and Centre of Clinical Neurosciences, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czechia.
  • John-Paul Taylor
    Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, United Kingdom.
  • John T O'Brien
    Institute of Neuroscience, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, NE4 5PL, United Kingdom.
  • Michael Firbank
    Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.
  • Alan Thomas
    Brains for Dementia Research Coordinating Centre, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom.
  • Paul C Donaghy
    Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.
  • Stephane Lehericy
    Institut du Cerveau et de la Moelle épinière, ICM, Sorbonne Université, Inserm 1127, CNRS UMR 7225, F-75013, Paris, France; Institut du Cerveau et de la Moelle épinière, ICM, Centre de NeuroImagerie de Recherche, CENIR, Paris, France.
  • Marie Vidailhet
    Sorbonne Université, Paris Brain Institute-ICM, INSERM U1127, CNRS UMR 7225, Pitié-Salpêtrière Hospital, Paris, France.
  • Jean-Christophe Corvol
    Sorbonne Université, Paris Brain Institute-ICM, INSERM U1127, CNRS UMR 7225, Pitié-Salpêtrière Hospital, Paris, France.
  • Iceberg Study Group
    Institut du Cerveau - Paris Brain Institute - ICM, Sorbonne Université, INSERM UMR 1127, CNRS 7225, Clinical Investigation Centre (CIC), Paris, 75013, France.
  • Richard Camicioli
    Neuroscience and Mental Health Institute and Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada.
  • Howard Chertkow
    Jewish General Hospital, Montreal, QC.
  • Simon Lewis
    Parkinson's Disease Research Clinic, Macquarie Medical School, Macquarie University, Sydney, Australia; Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Camperdown, NSW, 2050, Australia.
  • Elie Matar
    Parkinson's Disease Research Clinic, Macquarie Medical School, Macquarie University, Sydney, Australia.
  • Kaylena A Ehgoetz Martens
  • Lachlan Churchill
    Parkinson's Disease Research Clinic, Macquarie Medical School, Macquarie University, Sydney, Australia.
  • Michael Sommerauer
    Centre of Neurology, Department of Parkinson, Sleep and Movement Disorders, University Hospital Bonn, Bonn, Germany; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Neurology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Forschungszentrum Jülich, Jülich, Germany.
  • Sinah Röttgen
    Department of Neurology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Forschungszentrum Jülich, Jülich, Germany.
  • Per Borghammer
    Department of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, DK-8200, Denmark.
  • Karoline Knudsen
    Department of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, DK-8200, Denmark.
  • Allan K Hansen
    Department of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, DK-8200, Denmark.
  • Dario Arnaldi
    Department of Neuroscience, Rehabilitation, Opthalmology, Genetics and Maternal and Child Science (DINOGMI), University of Genoa Largo Paolo Daneo 3, 16132 Genoa, Italy.
  • Beatrice Orso
    Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Genoa, 16132, Italy.
  • Pietro Mattioli
    Department of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.
  • Luca Roccatagliata
    Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Genoa, 16132, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, 16132, Italy.
  • Oury Monchi
    Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. oury.monchi@ucalgary.ca.
  • Shady Rahayel
    Centre for Advanced Research in Sleep Medicine, CIUSSS-NÎM - Hôpital du Sacré-Cœur de Montréal, Montreal, H4J 1C5, Canada; Department of Medicine, University of Montreal, Montreal, H3T 1A4, Canada. Electronic address: shady.rahayel@umontreal.ca.

Keywords

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