ChatGPT-4o vs Psychiatrists in Responding to Common Antidepressant Concerns.

PurposeArtificial intelligence (AI) is increasingly integrated into healthcare, including psychiatric care. This study evaluates ChatGPT-4o's reliability in answering frequently asked antidepressant-related questions by comparing its performance with psychiatrists across four key dimensions: accuracy, conciseness, readability, and clarity.DesignA comparative study analyzing ChatGPT-4o-generated responses and those of psychiatrists with at least five years of clinical experience.SettingParticipants were recruited through institutional and professional networks and provided with standardized questions derived from authoritative treatment guidelines.SubjectsTwenty-six psychiatrists participated, and ChatGPT-4o responses were generated using a standardized prompt for each question.MeasuresTwo independent psychiatrists evaluated accuracy and conciseness using a blinded rating system. Readability was assessed with the Flesch-Kincaid Grade Level test, and clarity was measured with the Writing Clarity Index Calculator.AnalysisThe Shapiro-Wilk test assessed normality. Paired t-tests were used for normally distributed data, and the Wilcoxon signed-rank test for non-normally distributed data. Statistical significance was set at < .05.ResultsChatGPT-4o showed comparable accuracy to psychiatrists ( = .0645) but was significantly more concise ( = .0019). Readability differences were not statistically significant ( = .0892), while psychiatrists provided clearer responses ( = .0059).ConclusionChatGPT-4o delivers accurate and concise responses, highlighting its potential as a patient education tool. However, psychiatrists offer greater clarity, underscoring the indispensable role of clinical expertise in psychiatric care.