Effect of low-dose colchicine on pericoronary inflammation and coronary plaque composition in chronic coronary disease: a subanalysis of the LoDoCo2 trial.

Journal: Heart (British Cardiac Society)
Published Date:

Abstract

BACKGROUND: Low-dose colchicine (0.5 mg once daily) reduces the risk of major cardiovascular events in coronary disease, but its mechanism of action is not yet fully understood. We investigated whether low-dose colchicine is associated with changes in pericoronary inflammation and plaque composition in patients with chronic coronary disease.

Authors

  • Aernoud T L Fiolet
    Department of Cardiology, University Medical Center Utrecht, The Netherlands (A.T.L.F.).
  • Andrew Lin
    Biomedical Imaging Research Institute, Cedars-Sinai Medical Center , Los Angeles, CA, USA.
  • Jacek Kwiecinski
    Division of Artificial Intelligence in Medicine, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
  • Julie Tutein Nolthenius
    Faculty of Medicine, Amsterdam University Medical Centre Amsterdam, Amsterdam, The Netherlands.
  • Priscilla McElhinney
    Department of Biomedical Sciences, Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 116 N Robertson Blvd, Los Angeles, CA 90048, USA.
  • Kajetan Grodecki
    Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California.
  • Bas Kietselaer
    Department of Cardiology, Zuyderland Medical Center, H. Dunantstraat 5, 6419 PC, Heerlen, The Netherlands.
  • Tjerk S Opstal
    Department of Cardiology, Amsterdam University Medical Centre Amsterdam, Amsterdam, The Netherlands.
  • Jan Hein Cornel
    Dutch Network for Cardiovascular Research (WCN), Utrecht, The Netherlands.
  • Remco Jj Knol
    Cardiac Imaging Division, Department of Nuclear Medicine, Noordwest Ziekenhuisgroep, Alkmaar, Noord-Holland, The Netherlands.
  • Jeroen Schaap
    Department of Cardiology, Amphia Hospital, Breda, The Netherlands.
  • Ruud A H M Aarts
    Department of Radiology, Amphia Hospital, Breda, The Netherlands.
  • Annemieke M F A Tutein Nolthenius
    Department of Radiology, Meander MC, Amersfoort, The Netherlands.
  • Stefan M Nidorf
    Heart and Vascular Research Institute of Western Australia, Perth (S.M.N., P.L.T.).
  • Birgitta K Velthuis
    From the Image Sciences Institute (S.G.M.v.V., N.L., M.A.V., I.I.), Departments of Radiology (B.K.V., T.L., P.A.d.J., W.B.V.), Experimental Cardiology (I.E.M.B.), and Radiotherapy (D.H.J.G.v.d.B.), and Imaging Division (H.M.V.), University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands (N.L.); Departments of Biomedical Engineering and Physics (S.G.M.v.V., I.I.) and Radiology and Nuclear Medicine (I.I.), and Amsterdam Cardiovascular Sciences (I.I.), Amsterdam University Medical Center, University of Amsterdam, the Netherlands; Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, the Netherlands (N.L.); Department of Cardiology, Meander Medical Center, Amersfoort, the Netherlands (I.E.M.B.); Department of Medicine, University of Mississippi Medical Center, Jackson, Miss (A.C.); and Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tenn (J.G.T., J.J.C.).
  • Damini Dey
    Departments of Imaging and Medicine, and Cedars-Sinai Heart Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Taper A238, Los Angeles, CA, 90048, USA.
  • Arend Mosterd
    Dutch Network for Cardiovascular Research (Werkgroep Cardiologische centra Nederland), Utrecht, The Netherlands (A.T.L.F., A.M., L.B., R.d.N., J.H.C.).

Keywords

No keywords available for this article.