Cryo-ablation management of atrial fibrillation in Fabry disease without agalsidase alpha: a case report.

Journal: Frontiers in cardiovascular medicine
Published Date: May 30, 2025

Abstract

Fabry disease (FD) is a rare genetic disorder caused by mutations in the gene, affecting multiple organs. Over 60% of patients experience heart-related issues, primarily arrhythmias. Unlike typical cases, these arrhythmias are complex and often do not respond well to standard antiarrhythmic drugs, sometimes worsening symptoms. This paper presents a case study of a FD patient with paroxysmal atrial fibrillation successfully treated using bilateral pulmonary vein cryoablation, resulting in positive outcomes. Additionally, we conducted molecular docking studies for the first time to assess the enzyme-substrate binding of E358del, confirming findings similar to laboratory experiments. Our findings underscore the potential role of artificial intelligence in better understanding FD, and aim to provide insights into managing arrhythmias associated with FD.

Authors

  • Yuanzhu Li
    Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
  • Bi Huang
    School of Big Data and Intelligent Engineering, Southwest Forestry University, Kunming, China.
  • Suxin Luo
    Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, NO.1 Youyi Road, Yuzhong District, Chongqing, 400016, China. luosuxin0204@163.com.

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