Integrative single-cell and cell-free plasma RNA transcriptomics identifies biomarkers for early non-invasive AD screening.

Journal: Frontiers in aging neuroscience
Published Date: May 30, 2025

Abstract

INTRODUCTION: Data-driven omics approaches have rapidly advanced our understanding of the molecular heterogeneity of Alzheimer's disease (AD). However, limited by the unavailability of brain tissue, there is an urgent need for a non-invasive tool to detect alterations in the AD brain. Cell-free RNA (cfRNA), which crosses the blood-brain barrier, could reflect AD brain pathology and serve as a diagnostic biomarker.

Authors

  • Li Wu
    Institute of Food Science and Technology, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China.
  • Renxin Zhang
    State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
  • Yichao Wang
    School of Chemical & Environmental Engineering, China University of Mining and Technology-Beijing, 100083, China.
  • Shaoxing Dai
    State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.
  • Naixue Yang
    State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan, China.

Keywords

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