Integrative transcriptomics and single-cell transcriptomics analyses reveal potential biomarkers and mechanisms of action in papillary thyroid carcinoma.

Journal: Frontiers in genetics
Published Date: May 30, 2025

Abstract

OBJECTIVE: Papillary thyroid carcinoma (PTC) has a high recurrence rate and lacks reliable diagnostic biomarkers. This study aims to identify robust transcriptomic biomarkers for PTC diagnosis through integrative bioinformatics approaches and elucidate the cellular mechanisms underlying PTC pathogenesis at single-cell resolution.

Authors

  • Wanchen Cao
    School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
  • Kai Gao
    College of Intelligence Science and Technology, National University of Defense Technology, Changsha, Hunan, China.
  • Yi Zhao
    Department of Biostatistics and Health Data Science, Indiana University School of Medicine.

Keywords

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