Identifying and predicting headache trajectories among those with acute post-traumatic headache.

Journal: Headache
Published Date: May 30, 2025

Abstract

OBJECTIVES/BACKGROUND: Post-traumatic headache (PTH) is a common symptom following mild traumatic brain injury (mTBI). Currently, there is no identified way to accurately predict if, when, and at what pace a person will have PTH improvement. In our prior studies, we focused on predicting headache improvement at 3 months post-mTBI. However, that approach may overlook individual differences in how headaches evolve over time. This study aimed to identify individual subgroups based on their headache trajectories and to develop machine-learning (ML) models for early prediction of headache evolution.

Authors

  • Lingchao Mao
    School of Industrial and Systems Engineering, Georgia Tech, Atlanta, Georgia, USA.
  • Jing Li
    Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
  • Todd J Schwedt
    Department of Neurology, Mayo Clinic, Scottsdale, Arizona, United States of America.
  • Teresa Wu
    ASU-Mayo Center for Innovative Imaging, Tempe, Arizona, United States of America.
  • Katherine Ross
    Veterans Health Administration, Phoenix VA Health Care System, Phoenix, Arizona, USA.
  • Gina Dumkrieger
    Department of Neurology, Mayo Clinic, Phoenix, Arizona, USA.
  • Dani C Smith
    Department of Neurology, Mayo Clinic, Phoenix, Arizona, USA.
  • Catherine D Chong
    Department of Neurology, Mayo Clinic, Scottsdale, Arizona, United States of America.

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