Elevated Vitamin B12 Levels in Myeloproliferative Neoplasm (MPN) Patients: A Potential Diagnostic and Prognostic Marker.

Journal: Journal of blood medicine
Published Date: Dec 27, 2024

Abstract

BACKGROUND: Elevated vitamin B12 (B12) levels are linked to an increased risk of cancers, including hematological malignancies. This study focuses on the relationship between elevated B12 and myeloproliferative neoplasms (MPNs): Polycythemia Vera (PV), Primary Myelofibrosis (MF), Essential Thrombocytosis (ET), and Chronic Myeloid Leukemia (CML). Elevated B12 in MPNs is believed to arise from increased transcobalamin I (TCI) secretion by proliferating leukocytes, leading to higher serum levels. B12 may serve as a diagnostic and prognostic biomarker for these conditions. However, its sensitivity, specificity, and cutoff levels are unclear.

Authors

  • Abdalla Fadul
    Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.
  • Elmustafa Abdalla
    Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.
  • Anas Mohamed
    Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.
  • Bashir Ali
    Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.
  • Nusiba Elamin
    Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.
  • Ahmed Abdelghafar Alsayed
    Department of Internal Medicine, Hamad Medical Corporation, Doha, Qatar.
  • Abdulrahman F Al-Mashdali
    Department of Hematology, Hamad Medical Corporation, Doha, Qatar.
  • Kalpana Singh
    Department of medical biostatistics, Hamad Medical Corporation, Doha, Qatar.
  • Shehab F Mohamed
    Department of Hematology, Hamad Medical Corporation, Doha, Qatar.

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