Towards precision medicine strategies using plasma proteomic profiling for suspected gallbladder cancer: A pilot study.

Journal: JHEP reports : innovation in hepatology
Published Date: Feb 21, 2025

Abstract

BACKGROUND & AIMS: Currently, preoperative diagnostic methods that can distinguish cancer from benign disease of the gallbladder are insufficient, and several surgical resections can be avoided if the pathology is known prior to surgery. This study aimed to assess whether preoperative plasma proteins can distinguish gallbladder cancer (GBC) from cholecystitis, with the main goal of identifying proteins for multivariate description of the postoperative diagnosis, before surgery.

Authors

  • Ghada Nouairia
    Unit of Gastroenterology and Rheumatology, Department of Medicine Huddinge (MedH), Karolinska Institutet, Stockholm, Sweden.
  • Martin Cornillet
    Center for Infectious Medicine, Department of Medicine Huddinge (MedH), Karolinska Institutet, Stockholm, Sweden.
  • Hannes Jansson
    Division of Surgery and Oncology, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden. Electronic address: hannes.jansson@ki.se.
  • Annika Bergquist
    Division of Hepatology, Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden.
  • Ernesto Sparrelid
    Division of Surgery and Oncology, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden; Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden.

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