The mouse resource at National Resource Center for Mutant Mice of China.

Journal: Mammalian genome : official journal of the International Mammalian Genome Society
Published Date: Mar 27, 2025

Abstract

Mouse models serve as the most important laboratory resource for both biomedical research and preclinical study of drug development. National Resource Center of Mutant Mice (NRCMM) of China was initiated in 2001 and became one of the 31 members of National Science and Technology Resource Sharing Platform in 2019. Currently, NRCMM is co-managed by Model Animal Research Center of Nanjing University and Gempharmatech (GPT, a Shanghai Exchange enlisted public company). Dedicated to produce and collect genetic edited mouse models, NRCMM holds more than 22,000 mouse strains in 2024, compared with 18,500 strains reported in 2022. This review provides an update on our Knock-Out All Project (KOAP) and highlights resources available for immune system reconstitution models, disease models, and chromosome substitution strains at NRCMM.

Authors

  • Bingzhou Han
    National Resource Center for Mutant Mice, GemPharmatech Co., Ltd, Nanjing, China.
  • Dongshen Chen
    National Resource Center for Mutant Mice, Model Animal Research Center of Nanjing University, Nanjing, China.
  • Zhong Chen
    Institute of HIV/AIDS The First Hospital of Changsha, Changsha, China.
  • Ting Wang
    CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
  • Kaiyuan Zi
    National Resource Center for Mutant Mice, GemPharmatech Co., Ltd, Nanjing, China.
  • Rui Feng
    Department of Pharmacy, The Fourth Hospital of Hebei Medical University Shijiazhuang 050000, Hebei, China.
  • Xiaoliu Yang
    National Resource Center for Mutant Mice, GemPharmatech Co., Ltd, Nanjing, China.
  • Ling'en Li
    National Resource Center for Mutant Mice, GemPharmatech Co., Ltd, Nanjing, China.
  • Juan Liang
    National Resource Center for Mutant Mice, GemPharmatech Co., Ltd, Nanjing, China. liangjuan@gempharmatech.com.
  • Xiang Gao
    Department of Gastroenterology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, P. R. China.

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