Identification and Validation of Circadian Rhythm-Related Genes Involved in Intervertebral Disc Degeneration and Analysis of Immune Cell Infiltration via Machine Learning.

Journal: JOR spine
Published Date: Apr 13, 2025

Abstract

BACKGROUND: Low back pain is a significant burden worldwide, and intervertebral disc degeneration (IVDD) is identified as the primary cause. Recent research has emphasized the significant role of circadian rhythms (CRs) and immunity in affecting intervertebral discs (IVD). However, the influence of circadian rhythms and immunity on the mechanism of IVDD remains unclear. This study aimed to identify and validate key rhythm-related genes in IVDD and analyze their correlation with immune cell infiltration.

Authors

  • Yongbo Zhang
    Department of Orthopedics Northern Jiangsu People's Hospital Affiliated to Yangzhou University Yangzhou China.
  • Liuyang Chen
    Department of Orthopedics Northern Jiangsu People's Hospital Affiliated to Yangzhou University Yangzhou China.
  • Sheng Yang
    Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, China.
  • Rui Dai
    Department of Mathematics, Harbin Institute of Technology, Harbin, China. Electronic address: 13B912003@hit.edu.cn.
  • Hua Sun
    Taizhou Hospital, Zhejiang University School of Medicine, Taizhou, China.
  • Liang Zhang

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals