Exploring associations among pro-inflammatory cytokines, osteoarthritis, and gut microbiome composition in individuals with obesity using machine learning.

Journal: Osteoarthritis and cartilage open
Published Date: Mar 19, 2025

Abstract

OBJECTIVE: To investigate potentially novel and modifiable mechanisms of the effects of gut microbiome composition on obesity-related osteoarthritis (OA), focusing on cross-sectional relationships between microbiota, cytokines, and lipopolysaccharide (LPS).

Authors

  • Cameron Kurz
    Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Liubov Arbeeva
    L. Arbeeva, MS, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
  • M Andrea Azcarate-Peril
    Center for Gastrointestinal Biology and Disease (CGIBD), Department of Medicine, Division of Gastroenterology and Hepatology, School of Medicine, UNC Microbiome Core, University of North Carolina, Chapel Hill, NC, USA.
  • Delisha A Stewart
    Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA.
  • B Duncan X Lascelles
    Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Richard F Loeser
    Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
  • Amanda E Nelson
    Department of Epidemiology, Gillings School of Global Public Health.

Keywords

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