Pharmacological potential of bioactive compounds in extract: A comprehensive review.

Journal: Toxicology reports
Published Date: Mar 17, 2025

Abstract

The pharmacological potential of bioactive compounds found in the plant, , have diverse medicinal applications. Key constituents such as vinblastine and vincristine play an important role in cancer therapy due to their ability to disrupt microtubule function resulting in cell death in cancers such as neuroblastoma and leukemia. Beyond oncology, extracts show promise as antidiabetic agents by regulating glucose metabolism and improving lipid profiles in animal models. The plant's antibacterial properties make it a potential candidate for combating infectious diseases, including those caused by multidrug-resistant pathogens. Moreover, compounds derived from exhibit anti-inflammatory effects by modulating cytokine synthesis suggesting potential applications in treating inflammatory conditions. Recent research has uncovered potential neuroprotective properties opening avenues for neurodegenerative disorder treatments. There are currently challenges in refining extraction methods and enhancing component purity of the extracts. Advancements in genetic engineering and high-performance liquid chromatography offer promising avenues for addressing these issues. CRISPR-Cas9 and machine learning are being explored to enhance alkaloid production and optimize cultivation conditions. Looking ahead, nanotechnology-based drug delivery systems hold the potential to enhance drug bioavailability and efficacy while reducing adverse effects. Additionally, exploring synergistic effects between these alkaloids and other compounds presents exciting possibilities in drug discovery. emerges as a valuable reservoir of bioactive compounds with significant implications for pharmacology. Integrating traditional medicine with modern technologies promises to unlock new possibilities in drug development, potentially revolutionizing treatment strategies across various therapeutic domains.

Authors

  • Keren Celestina Mendonce
    Department of Biotechnology, Faculty of Science and Humanities, SRM Institute of Science and Technology, Chengalpattu District, Kattankulathur, Tamil Nadu 603203, India.
  • Naveen Palani
    Department of Physics and Nanotechnology, SRM Institute of Science and Technology, Chengalpattu District, Kattankulathur, Tamil Nadu 603203, India.
  • Suriyaprakash Rajadesingu
    Centre for Research in Environment, Sustainability Advocacy and Climate Change (REACH), Directorate of Research, SRM Institute of Science and Technology, Chengalpattu District, Kattankulathur, Tamil Nadu 603203, India.
  • K Radhakrishnan
    Department of Chemistry, Centre for Material Chemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu 641021, India.
  • Manikandan Ayyar
    Department of Chemistry, Centre for Material Chemistry, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu 641021, India.
  • L Srimathi Priya
    Department of Natural Resource Management, Horticultural College and Research Institute (HC & RI), Tamil Nadu Agricultural University (TNAU), Periyakulam, Theni, Tamil Nadu 625604, India.

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