Retrospective Comparative Analysis of Prostate Cancer In-Basket Messages: Responses From Closed-Domain Large Language Models Versus Clinical Teams.

Journal: Mayo Clinic proceedings. Digital health
Published Date: Feb 7, 2025

Abstract

OBJECTIVE: To evaluate the effectiveness of RadOnc-generative pretrained transformer (GPT), a GPT-4 based large language model, in assisting with in-basket message response generation for prostate cancer treatment, with the goal of reducing the workload and time on clinical care teams while maintaining response quality.

Authors

  • Yuexing Hao
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ (Y.H., J.H., S.H.P., N.Y.Y., W.L.); Cornell University, Ithaca, NY (Y.H.); Department of Electric Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (Y.H.); and Department of Radiation Oncology, Mayo Clinic, Rochester, MN (A.B., E.L.M., D.K.E., D.M.R., S.S., C.L.H., B.E.B., M.W.).
  • Jason Holmes
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ (Y.H., J.H., S.H.P., N.Y.Y., W.L.); Cornell University, Ithaca, NY (Y.H.); Department of Electric Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (Y.H.); and Department of Radiation Oncology, Mayo Clinic, Rochester, MN (A.B., E.L.M., D.K.E., D.M.R., S.S., C.L.H., B.E.B., M.W.).
  • Jared Hobson
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ (Y.H., J.H., S.H.P., N.Y.Y., W.L.); Cornell University, Ithaca, NY (Y.H.); Department of Electric Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (Y.H.); and Department of Radiation Oncology, Mayo Clinic, Rochester, MN (A.B., E.L.M., D.K.E., D.M.R., S.S., C.L.H., B.E.B., M.W.).
  • Alexandra Bennett
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ (Y.H., J.H., S.H.P., N.Y.Y., W.L.); Cornell University, Ithaca, NY (Y.H.); Department of Electric Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (Y.H.); and Department of Radiation Oncology, Mayo Clinic, Rochester, MN (A.B., E.L.M., D.K.E., D.M.R., S.S., C.L.H., B.E.B., M.W.).
  • Elizabeth L McKone
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ (Y.H., J.H., S.H.P., N.Y.Y., W.L.); Cornell University, Ithaca, NY (Y.H.); Department of Electric Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (Y.H.); and Department of Radiation Oncology, Mayo Clinic, Rochester, MN (A.B., E.L.M., D.K.E., D.M.R., S.S., C.L.H., B.E.B., M.W.).
  • Daniel K Ebner
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ (Y.H., J.H., S.H.P., N.Y.Y., W.L.); Cornell University, Ithaca, NY (Y.H.); Department of Electric Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (Y.H.); and Department of Radiation Oncology, Mayo Clinic, Rochester, MN (A.B., E.L.M., D.K.E., D.M.R., S.S., C.L.H., B.E.B., M.W.).
  • David M Routman
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ (Y.H., J.H., S.H.P., N.Y.Y., W.L.); Cornell University, Ithaca, NY (Y.H.); Department of Electric Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (Y.H.); and Department of Radiation Oncology, Mayo Clinic, Rochester, MN (A.B., E.L.M., D.K.E., D.M.R., S.S., C.L.H., B.E.B., M.W.).
  • Satomi Shiraishi
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ (Y.H., J.H., S.H.P., N.Y.Y., W.L.); Cornell University, Ithaca, NY (Y.H.); Department of Electric Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (Y.H.); and Department of Radiation Oncology, Mayo Clinic, Rochester, MN (A.B., E.L.M., D.K.E., D.M.R., S.S., C.L.H., B.E.B., M.W.).
  • Samir H Patel
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ (Y.H., J.H., S.H.P., N.Y.Y., W.L.); Cornell University, Ithaca, NY (Y.H.); Department of Electric Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (Y.H.); and Department of Radiation Oncology, Mayo Clinic, Rochester, MN (A.B., E.L.M., D.K.E., D.M.R., S.S., C.L.H., B.E.B., M.W.).
  • Nathan Y Yu
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ (Y.H., J.H., S.H.P., N.Y.Y., W.L.); Cornell University, Ithaca, NY (Y.H.); Department of Electric Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (Y.H.); and Department of Radiation Oncology, Mayo Clinic, Rochester, MN (A.B., E.L.M., D.K.E., D.M.R., S.S., C.L.H., B.E.B., M.W.).
  • Chris L Hallemeier
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ (Y.H., J.H., S.H.P., N.Y.Y., W.L.); Cornell University, Ithaca, NY (Y.H.); Department of Electric Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (Y.H.); and Department of Radiation Oncology, Mayo Clinic, Rochester, MN (A.B., E.L.M., D.K.E., D.M.R., S.S., C.L.H., B.E.B., M.W.).
  • Brooke E Ball
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ (Y.H., J.H., S.H.P., N.Y.Y., W.L.); Cornell University, Ithaca, NY (Y.H.); Department of Electric Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (Y.H.); and Department of Radiation Oncology, Mayo Clinic, Rochester, MN (A.B., E.L.M., D.K.E., D.M.R., S.S., C.L.H., B.E.B., M.W.).
  • Mark Waddle
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ (Y.H., J.H., S.H.P., N.Y.Y., W.L.); Cornell University, Ithaca, NY (Y.H.); Department of Electric Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (Y.H.); and Department of Radiation Oncology, Mayo Clinic, Rochester, MN (A.B., E.L.M., D.K.E., D.M.R., S.S., C.L.H., B.E.B., M.W.).
  • Wei Liu
    Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, United States.

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