Self-organizing maps to aid prognostic and diagnostic biomarker identification in exploratory metabolomics of benign prostatic hyperplasia.

Journal: Metabolomics : Official journal of the Metabolomic Society
Published Date: Jun 19, 2025

Abstract

INTRODUCTION: Population aging is increasing rapidly, representing a global trend that has launched many discussions regarding older adult's quality of life. Benign prostatic hyperplasia (BPH) is a commonly found condition among older men, affecting the lower urinary tract and quality of life. BPH diagnosis typically involves clinical evaluations which cannot accurately identify patients who will develop a clinically significant disease in the future. Metabolomics emerges as a promising approach to understand the metabolic pathways associated with BPH, offering potential aid in early diagnosis.

Authors

  • André Luiz Melo Camelo
    Laboratory of Analysis of Biomolecules Tiselius, Department of Analytical Chemistry, Institute of Chemistry, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • André Matos de Oliveira
    Division of Urology, School of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil.
  • Hans Rolando Zamora-Obando
    Laboratory of Analysis of Biomolecules Tiselius, Department of Analytical Chemistry, Institute of Chemistry, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Aline Cristina Dias
    Laboratory of Analysis of Biomolecules Tiselius, Department of Analytical Chemistry, Institute of Chemistry, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Thaís de Assis Lopes
    SEPARARE-Chromatography Research Center, Department of Chemistry, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
  • Regina Vincenzi Oliveira
    SEPARARE-Chromatography Research Center, Department of Chemistry, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
  • João Pedro Simon Farah
    Department of Fundamental Chemistry, Institute of Chemistry, University of Sao Paulo, Sao Paulo, Brazil.
  • Marina Franco Maggi Tavares
    Center for Multiplatform Metabolomics Studies (CEMM), Institute of Chemistry, University of São Paulo, São Paulo, São Paulo, Brazil.
  • Maggi Tavares
    Center for Multiplatform Metabolomics Studies (CEMM), Institute of Chemistry, University of São Paulo, São Paulo, São Paulo, Brazil.
  • Alberto Azoubel Antunes
    Division of Urology, School of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil. antunesuro@uol.com.br.
  • Ana Valéria
    Laboratory of Analysis of Biomolecules Tiselius, Department of Analytical Chemistry, Institute of Chemistry, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil.
  • Colnaghi Simionato
    Laboratory of Analysis of Biomolecules Tiselius, Department of Analytical Chemistry, Institute of Chemistry, Universidade Estadual de Campinas (UNICAMP), Campinas, São Paulo, Brazil. avsimionato@unicamp.br.

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