Functional connectivity alterations of the pregenual anterior cingulate cortex by ketamine and the modulation by lamotrigine.

Journal: Journal of psychopharmacology (Oxford, England)
Published Date: Jun 19, 2025

Abstract

BACKGROUND: Neuroimaging studies have linked the beneficial effects of subanaesthetic ketamine doses in psychiatric conditions characterized by chronic stress pathology (CSP) to altered functional connectivity (FC) within the pregenual anterior cingulate cortex (pgACC). Previous research indicates a potential role of glutamate concentration in FC changes; however, the precise relationship between glutamate release and increased FC remains unclear. Lamotrigine, a glutamate-release inhibitor, allows deeper exploration of this relationship. Additionally, CSP and treatment efficacy are closely associated with alterations in working memory (WM), necessitating the examination of FC during resting state and WM tasks.

Authors

  • David Weigner
    Institute of Neuroscience and Biopsychology for Clinical Application, Medical School Berlin, Berlin, Germany.
  • Marvin Sören Meiering
    Institute of Neuroscience and Biopsychology for Clinical Application, Medical School Berlin, Berlin, Germany.
  • Anne Weigand
    Institute of Neuroscience and Biopsychology for Clinical Application, Medical School Berlin, Berlin, Germany.
  • Luisa Carstens
    Institute of Neuroscience and Biopsychology for Clinical Application, Medical School Berlin, Berlin, Germany.
  • Christian Keicher
    Charité Research Organization GmbH, Berlin, Germany.
  • Rita Hertrampf
    Charité Research Organization GmbH, Berlin, Germany.
  • Christian Beckmann
    SBGneuro Ltd., Oxford, UK.
  • Maarten Mennes
    Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Andreas Wunder
    Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss, Germany.
  • Matti Gärtner
    Institute of Neuroscience and Biopsychology for Clinical Application, Medical School Berlin, Berlin, Germany.
  • Simone Grimm
    Institute of Neuroscience and Biopsychology for Clinical Application, Medical School Berlin, Berlin, Germany.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals