Comparative cytokine signatures and cognitive deficits in early-onset schizophrenia and adolescent major depression: Toward refined diagnostic classification frameworks.

Journal: Journal of affective disorders
Published Date: Jun 16, 2025

Abstract

BACKGROUND: This study analyzed plasma cytokine patterns in individuals with schizophrenia (SCZ), major depressive disorder (MDD), and healthy controls, explored the link between cytokine levels and cognitive function, and created machine learning models to evaluate the diagnostic potential of cytokine and cognitive assessments.

Authors

  • Xing Luo
    College of Mechanical and Control Engineering, Guilin University of Technology, Guilin, Guangxi 541004, China.
  • Jiangwen Dong
    Affiliated Mental Health Centre, Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, 305 Tianmushan Road, Hangzhou, Zhejiang 310013, China.
  • Tao Li
    Department of Emergency Medicine, Jining No.1 People's Hospital, Jining, China.

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