Microbiome multi-omics analysis reveals novel biomarkers and mechanisms linked with CD etiopathology.

Journal: Biomarker research
Published Date: Jun 16, 2025

Abstract

BACKGROUND: The gut microbiome plays a key role in the development of inflammatory bowel disease (IBD), as imbalances in microbial composition are associated with immune dysfunction. However, the specific mechanisms by which certain microorganisms contribute to this process remain unclear.

Authors

  • Gerard Serrano-Gómez
    Microbiome Lab, Vall d'Hebron Institut de Recerca (VHIR), 119-129 pg Vall d'Hebron, Barcelona, 08035, Spain.
  • Francisca Yañez
    Microbiome Lab, Vall d'Hebron Institut de Recerca (VHIR), 119-129 pg Vall d'Hebron, Barcelona, 08035, Spain.
  • Zaida Soler
    Microbiome Lab, Vall d'Hebron Institut de Recerca (VHIR), 119-129 pg Vall d'Hebron, Barcelona, 08035, Spain.
  • Marc Pons-Tarin
    Microbiome Lab, Vall d'Hebron Institut de Recerca (VHIR), 119-129 pg Vall d'Hebron, Barcelona, 08035, Spain.
  • Luis Mayorga
    Microbiome Lab, Vall d'Hebron Institut de Recerca (VHIR), 119-129 pg Vall d'Hebron, Barcelona, 08035, Spain.
  • Claudia Herrera-deGuise
    Microbiome Lab, Vall d'Hebron Institut de Recerca (VHIR), 119-129 pg Vall d'Hebron, Barcelona, 08035, Spain.
  • Natalia Borruel
    Microbiome Lab, Vall d'Hebron Institut de Recerca (VHIR), 119-129 pg Vall d'Hebron, Barcelona, 08035, Spain.
  • Antonio Rodriguez-Sinovas
    Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
  • Marta Consegal
    Cardiovascular Diseases Research Group, Department of Cardiology, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
  • Isaac Manjón
    Microbiome Lab, Vall d'Hebron Institut de Recerca (VHIR), 119-129 pg Vall d'Hebron, Barcelona, 08035, Spain.
  • Sara Vega-Abellaneda
    Microbiome Lab, Vall d'Hebron Institut de Recerca (VHIR), 119-129 pg Vall d'Hebron, Barcelona, 08035, Spain.
  • Chaysavanh Manichanh
    Microbiome Lab, Vall d'Hebron Institut de Recerca (VHIR), 119-129 pg Vall d'Hebron, Barcelona, 08035, Spain. cmanicha@gmail.com.

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