Identifying Clinical Research Priorities in Interventional Pulmonary: An Interventional Pulmonology Outcomes Group (IPOG) Working Group Report.

Journal: Annals of the American Thoracic Society
Published Date: Jun 16, 2025

Abstract

The field of Interventional Pulmonology suffers from a paucity of methodologically robust studies to inform patient care, often relying on retrospective, single-center, non-comparative cohorts of commercialized products. The Interventional Pulmonary Outcomes Group (IPOG) was established to address the critical need for increased scientific rigor within the Interventional Pulmonology community. IPOG convened a meeting to assess the current state and future needs for minimally invasive lung cancer diagnostics and treatment. The goals of this meeting were to review the current landscape, and identify gaps and barriers in lung cancer diagnostics and therapeutics research. From this discussion short- and long-term research goals and priorities were identified. Nineteen international experts from various institutions and disciplines participated. The top short-term priorities identified were: 1) harmonization of core outcome measures in interventional pulmonology trials, 2) validation of a pathway/structure for the introduction of new technology, 3) establishment of a patient advisory board with focus on patient centered outcomes, 4) early engagement with industry partnerships during clinical trial design. The top long-term priorities identified were: 1) characterize the development, implementation, and role of bronchoscopic ablation, 2) validation and clinical utility of biomarker use and artificial intelligence, 3) implement research training skills for junior investigators in interventional pulmonology, 4) deliver 5 prospective, large clinical trials, with at least one adaptive trial, 5) develop a biorepository accessible to investigators. This perspective reviews the colloquium discussions, the identified priorities and the plans to help address those priorities as well as progress made in the year since its inception. Keywords: Interventional Pulmonology Outcomes Group; Interventional Pulmonology; Lung Cancer; Research; Outcomes.

Authors

  • Jeffrey Thiboutot
    Johns Hopkins School of Medicine, Division of Pulmonary and Critical Care Medicine, Baltimore, Maryland, United States.
  • Lonny B Yarmus
    Johns Hopkins University, Pulmonary and Critical Care, Baltimore, Maryland, United States.
  • Fabien Maldonado
    Mechanical Engineering Department, Vanderbilt University, Nashville, TN, USA.
  • Gerard Silvestri
    Medical University of South Carolina, Charleston, SC, USA.
  • Anil Vachani
    Division of Pulmonary, Allergy and Critical Care Medicine, Thoracic Oncology Group, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States; Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
  • Momen Wahidi
    Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.
  • Anne Gonzalez
    McGill Universith Health Centre, Respiratory Epidemiology and Clinical Research Unit, Montreal, Quebec, Canada.
  • Angela Christine Argento
    Johns Hopkins Medicine School of Medicine, Baltimore, Maryland, United States.
  • Hans J Lee
    Johns Hopkins University, DIvision of Pulmonary/ Critical Care , Baltimore, Maryland, United States.
  • Peter Mazzone
    Cleveland Clinic, Cleveland, United States.
  • Felix Herth
    Thoraxklinik at University Hospital Heidelberg, Pulmonology and Critical Care Medicine, Heidelberg, Germany.
  • Alexander Chen
    Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, No.123, Dapi Rd., Niaosong Dist., Kaohsiung, 833, Taiwan, ROC.
  • Jason Akulian
    Department of Medicine, Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Y C Gary Lee
    University of Western Australia, School of Medicine, Perth, Western Australia, Australia.
  • Neal Navani
    Lungs for Living Research Centre, UCL Respiratory, University College London, London, UK.
  • Christopher Kapp
    Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States.
  • David Feller-Kopman
    Dartmouth-Hitchcock Medical Center, Department of Pulmonary and Critical Care Medicine, Lebanon, New Hampshire, United States.
  • Nick A Maskell
    University of Bristol, Academic Respiratory Unit, Bristol, United Kingdom of Great Britain and Northern Ireland.
  • Pallav L Shah
    Royal Brompton and Harefield NHS Foundation Trust, London, London, United Kingdom of Great Britain and Northern Ireland.
  • Andrew DeMaio
    New York University Grossman School of Medicine, Pulmonary Medicine, Interventional Pulmonology, New York, New York, United States.
  • Moishe Liberman
    Division of Thoracic Surgery, University of Montréal, Montréal, Québec, Canada; CETOC (CHUM Endoscopic Tracheobronchial and Oesophageal Center), Centre Hospitalier de l'Université de Montréal, Montréal, Québec, Canada. Electronic address: moishe.liberman@umontreal.ca.
  • Fergus Gleeson
    Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingdom.
  • Alastair J Moore
    Oxford University Hospitals NHS Foundation Trust, Oxford Centre for Respiratory Medicine, Oxford, United Kingdom of Great Britain and Northern Ireland.
  • Erik H F M van der Heijden
    Radboudumc, Pulmonary Diseases, Nijmegen, Netherlands.
  • Eihab O Bedawi
    The University of Sheffield, Department of Infection, Immunity and Cardiovascular Disease, Sheffield, United Kingdom of Great Britain and Northern Ireland.
  • Jason Beattie
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States.
  • Najib M Rahman
    Division of Cardiovascular Medicine, Radcliffe Department of Medicine, National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC), University of Oxford, Oxford, UK.
  • Christopher R Gilbert
    Medical University of South Carolina, Division of Pulmonary and Critical Care Medicine, Charleston, South Carolina, United States; gilberch@musc.edu.

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