Coarse Grain Preference, Gut Microbiota Features, in Relation to Hypertriglyceridemia in Constipation Patients: A Cross-Sectional Study.

Journal: Molecular nutrition & food research
Published Date:

Abstract

Coarse grain (CG) benefits blood lipids involving gut microbiota regulations. Little is known about the relation between CG preference and blood lipids in constipation patients, and related gut microbiota features. Gut microbial genera and dietary information of 249 functional constipation participants are characterized by 16S rRNA sequencing and a food frequency questionnaire. CG preference was defined as a higher CG intake frequency than refined grain (RG) intake frequency. Compared with RG, CG preference was associated with a lower serum triglyceride (TG) (p = 0.015) and a lower risk of hypertriglyceridemia (HTG). The reallocations from RG to CG at frequencies of 3, 5, and 10 times per week were associated with reductions in the risk of HTG by 48%, 67%, and 89%, respectively. A machine learning based model using gut microbiota features well identified the likelihood of HTG, with the area under the curve achieving 0.79 (95% CI, 0.65-0.91). Furthermore, the microbiome risk score profiling HTG was negatively correlated with CG preference (r = -0.150, p = 0.021). Preferring coarse grain as a staple food was associated with lower HTG risk and differential gut microbiota features in constipation patients.

Authors

  • Wei Li
    Department of Nephrology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
  • Menghan Wang
    Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Department of Epidemiology and Biostatistics, School of Public Health, Global Health Institute Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.
  • Kun Xu
    Department of Hygienic Inspection, School of Public Health, Jilin University 1163 Xinmin Street Changchun 130021 Jilin China songxiuling@jlu.edu.cn li_juan@jlu.edu.cn jinmh@jlu.edu.cn +86 43185619441.
  • Juan He
    Department of Clinical Laboratory Medicine Center, Inner Mongolia Autonomous Region People's Hospital, Hohhot, Inner Mongolia, China.
  • Xinran Feng
    Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Department of Epidemiology and Biostatistics, School of Public Health, Global Health Institute Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.
  • Guoqing Ma
    College of Mechanical and Electrical Engineering, Changchun University of Science and Technology, Changchun 130022, Jilin, China.
  • Yunfeng Li
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California at Los Angeles (UCLA), Los Angeles, California, USA.
  • Hao Lai
    Department of Cardiovascular Surgery, Zhongshan Hospital Fudan University.
  • Amei Tang
    Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Department of Epidemiology and Biostatistics, School of Public Health, Global Health Institute, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
  • Chen He
    The Elderly of Treatment Department of Critical Medicine, The Frist Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China.
  • Yifei He
    Department of EECS, University of Michigan, Ann Arbor, Michigan, USA.
  • Kaizhen Jia
    Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Department of Epidemiology and Biostatistics, School of Public Health, Global Health Institute Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China.
  • Xia Liao
    State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural Universitygrid.35155.37, Wuhan, China.
  • Hang Yu
  • Tian Tian
    Laboratory Animal Center College of Animal Science Jilin University Changchun China.
  • Xin Liu
    Peking University Institute of Advanced Agricultural Sciences, Shandong Laboratory of Advanced Agricultural Sciences, Weifang, Shandong, China.

Keywords

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