Chemokine-like factor-like MARVEL transmembrane domain-containing 1 identified as a novel target protein for immune dysregulation in sepsis: A machine learning and molecular dynamics framework for diagnostic biomarkers and therapeutic exploration.

Journal: International journal of biological macromolecules
Published Date:

Abstract

BACKGROUND: Sepsis, a systemic inflammatory response syndrome precipitated by infection, involves critical immune dysregulation. Here, we aimed to evaluate immune-derived diagnostic markers, investigate immune cell infiltration, and explore targeted pharmacological interventions.

Authors

  • Jingnan Lin
    The First Clinical Medical School of Guangzhou University of Chinese Medicine, Guangzhou 510000, China.
  • Kaiqiang Zhong
    The First Affiliated Hospital of Guangzhou University of Chinese Medicine & Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou 510405, China.
  • Shuqi Ma
    The Second Affiliated Hospital of Guangzhou University of Chinese Medicine & Guangdong Provincial Key Laboratory of Research on Emergency in Traditional Chinese Medicine, Guangzhou 510120, China.
  • Qiusha Pan
    The Second Affiliated Hospital of Guangzhou University of Chinese Medicine & Guangdong Provincial Key Laboratory of Research on Emergency in Traditional Chinese Medicine, Guangzhou 510120, China.
  • Shiyi Liu
    The First Affiliated Hospital of Guangzhou University of Chinese Medicine & Guangdong Clinical Research Academy of Chinese Medicine, Guangzhou 510405, China.
  • Ruifeng Zeng
    The Second Affiliated Hospital of Guangzhou University of Chinese Medicine & Guangdong Provincial Key Laboratory of Research on Emergency in Traditional Chinese Medicine, Guangzhou 510120, China.
  • Xiaotu Xi
    The Second Affiliated Hospital of Guangzhou University of Chinese Medicine & Guangdong Provincial Key Laboratory of Research on Emergency in Traditional Chinese Medicine, Guangzhou 510120, China.
  • Jun Li
    Department of Emergency, Zhuhai Integrated Traditional Chinese and Western Medicine Hospital, Zhuhai, 519020, Guangdong Province, China. quanshabai43@163.com.
  • Chen Rui
    The Second Affiliated Hospital of Guangzhou University of Chinese Medicine & Guangdong Provincial Key Laboratory of Research on Emergency in Traditional Chinese Medicine, Guangzhou 510120, China. Electronic address: happydecr@163.com.

Keywords

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