Deciphering the transcriptomic characteristic of lactate metabolism and the immune infiltration landscape in abdominal aortic aneurysm.

Journal: Biochemical and biophysical research communications
Published Date: Jun 14, 2025

Abstract

BACKGROUND: Abdominal aortic aneurysm (AAA) is a common degenerative vascular disease characterized by progressive dilation of the abdominal aorta, which poses a life-threatening risk upon rupture. Lactate, a key metabolic byproduct and immunomodulatory molecule, plays a crucial role in regulating immune cell functions in various inflammatory diseases. However, the specific involvement of lactate metabolism in the pathogenesis of AAA remains poorly understood. This study aims to identify lactate metabolism-related gene signatures associated with AAA and to elucidate their potential roles and underlying mechanisms in disease progression.

Authors

  • Min Zhang
    Department of Infectious Disease, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Ru Ying
    Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China; Jiangxi Hypertension Research Institute, Nanchang, China.
  • Song Lu
    Department of Cardiology, The First Affiliated Hospital of Nanchang University, Nanchang, China; Jiangxi Hypertension Research Institute, Nanchang, China.

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