Predicting pulmonary hemodynamics in pediatric pulmonary arterial hypertension using cardiac magnetic resonance imaging and machine learning: an exploratory pilot study.

Journal: The international journal of cardiovascular imaging
Published Date: Jun 14, 2025

Abstract

PURPOSE: Pulmonary arterial hypertension (PAH) significantly affects the pulmonary vasculature, requiring accurate estimation of mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance index (PVRi). Although cardiac catheterization is the gold standard for these measurements, it poses risks, especially in children. This pilot study explored how machine learning (ML) can predict pulmonary hemodynamics from non-invasive cardiac magnetic resonance (CMR) cine images in pediatric PAH patients.

Authors

  • Hung Chu
    Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Rosaria J Ferreira
    Center for Congenital Heart Diseases, Department of Paediatric Cardiology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Hanzeplein 1, PO Box 30.001, Groningen, 9700 RB, The Netherlands.
  • Chantal Lokhorst
    Center for Congenital Heart Diseases, Department of Paediatric Cardiology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Hanzeplein 1, PO Box 30.001, Groningen, 9700 RB, The Netherlands.
  • Johannes M Douwes
    Center for Congenital Heart Diseases, Department of Paediatric Cardiology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Hanzeplein 1, PO Box 30.001, Groningen, 9700 RB, The Netherlands.
  • Meindina G Haarman
    Center for Congenital Heart Diseases, Department of Paediatric Cardiology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Hanzeplein 1, PO Box 30.001, Groningen, 9700 RB, The Netherlands.
  • Tineke P Willems
    Center for Congenital Heart Diseases, Department of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Rolf M F Berger
    Center for Congenital Heart Diseases, Department of Paediatric Cardiology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Hanzeplein 1, PO Box 30.001, Groningen, 9700 RB, The Netherlands.
  • Mark-Jan Ploegstra
    Center for Congenital Heart Diseases, Department of Paediatric Cardiology, Beatrix Children's Hospital, University of Groningen, University Medical Center Groningen, Hanzeplein 1, PO Box 30.001, Groningen, 9700 RB, The Netherlands. m.ploegstra@umcg.nl.

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