Integrating Machine Learning Algorithms to Construct a Triaptosis-Related Prognostic Model in Melanoma.

Journal: Cancer management and research
Published Date: Jun 13, 2025

Abstract

INTRODUCTION: Melanoma is a highly aggressive skin cancer that accounts for a disproportionate number of skin cancer-related deaths due to early metastasis and therapy resistance. Programmed cell death (PCD), including ferroptosis and apoptosis, plays a crucial role in tumor progression and therapy response. Among these, triaptosis is a newly described form of PCD. It represents a novel mechanism of cell death with potential implications for cancer treatment. However, its role in melanoma remains largely unexplored.

Authors

  • Jiaheng Xie
    Department of Management Information Systems, University of Arizona, Tucson, AZ, USA.
  • Min Zhang
    Department of Infectious Disease, The Second Xiangya Hospital of Central South University, Changsha, China.
  • Min Qi
    Zhejiang Key Laboratory of Excited-State Energy Conversion and Energy Storage, Institute of Analytical Chemistry, Department of Chemistry, Zhejiang University, Hangzhou 310058, China.

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