Searching for peripheral proteomic markers of primary aldosteronism.

Journal: Endocrine
Published Date: Jun 13, 2025

Abstract

PURPOSE: Primary aldosteronism (PA) is prevalent among hypertensive patients, and associated with worsened cardiovascular outcomes compared to essential hypertension (HT). Screening and diagnostics for PA are currently complicated and invasive, why new methods are needed. Unilateral PA (uPA) is best treated surgically, and bilateral PA (bPA) - medically. No validated proteomic diagnostic test has been found yet. Our aim was to explore proteomic markers in peripheral serum to discriminate between HT, PA, uPA and bPA.

Authors

  • Nikita Makhnov
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden. nikita.makhnov@uu.se.
  • Fredrik Axling
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
  • Elham Barazeghi
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
  • Peter Stålberg
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
  • Tobias Åkerström
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
  • Per Hellman
    Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Keywords

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