Machine learning using serial changes in proteinuria during initial steroid therapy to predict treatment response and immunosuppressant use in pediatric idiopathic nephrotic syndrome.

Journal: Clinical and experimental nephrology
Published Date:

Abstract

BACKGROUND: Epidemiological studies on idiopathic nephrotic syndrome (INS) in children have identified no definitive factors predicting steroid-resistant nephrotic syndrome (SRNS) or frequent relapsing nephrotic syndrome. Research using machine learning (ML) has been conducted to predict INS prognosis; however, no studies have evaluated serial changes in proteinuria during initial steroid therapy.

Authors

  • Takaya Iida
    Centre for Critical Illness Research, Lawson Health Research Institute, London, ON N6A 5W9, Canada.
  • Kenichiro Miura
    Department of Pediatric Nephrology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
  • Takayuki Okamoto
    Department of Pediatrics, Hokkaido University Hospital, Sapporo, Japan.
  • Shuichiro Fujinaga
    Division of Nephrology, Saitama Children's Medical Center, Saitama, Japan.
  • Yuko Akioka
    Department of Pediatrics, Saitama Medical University, Saitama, Japan.
  • Yasuhiro Takeshima
    Department of Pediatrics, Hyogo Medical University, Nishinomiya, Hyogo, Japan.
  • Maki Urushihara
    Department of Pediatrics, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
  • Masataka Hisano
    Department of Nephrology, Chiba Children's Hospital, Chiba, Japan.
  • Yoshimitsu Gotoh
    Department of Pediatric Nephrology, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan.
  • Toshiyuki Ohta
    Department of Pediatric Nephrology, Hiroshima Prefectural Hospital, Hiroshima, Japan.
  • Eichi Takaya
    Graduate School of Science and Technology, Keio University.
  • Carlos Makoto Miyauchi
    AI Lab, Tohoku University Hospital, Sendai, Japan.
  • Shinya Sonobe
    AI Lab, Tohoku University Hospital, Sendai, Japan.
  • Tadashi Kaname
    Department of Genome Medicine, National Center for Child Health and Development, Tokyo, Japan.
  • Motoshi Hattori
    Department of Pediatric Nephrology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. hattori@twmu.ac.jp.

Keywords

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