Identification of stemness subtypes and prognostic modeling in thyroid cancer: the critical role of DPYSL3 in tumor progression and immune microenvironment.

Journal: Discover oncology
Published Date:

Abstract

PURPOSE: The objective of this study was to develop and evaluate a novel classifier and prognostic model based on the stemness characteristics of thyroid cancer patients.

Authors

  • Jialong Yu
    Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Henan,  China.
  • Wei Luo
    Centre for Pattern Recognition and Data Analytics, School of Information Technology, Deakin University, Geelong, Victoria, Australia.
  • Guangwei Xu
    Key Laboratory of Microelectronic Devices & Integrated Technology, Institute of Microelectronics of Chinese Academy of Sciences, Beijing 100029, China.
  • Mei Tao
    Department of Thyroid and Neck Tumor, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, No. 1, Huanhu West Road, Tianjin, 300060, China.
  • Yuqi Wang
    Graduate School at Shenzhen, Tsinghua University, Shenzhen, Guangdong, P.R. China.
  • Qiman Dong
    Department of Thyroid and Neck Tumor, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
  • Linfei Hu
    Department of Thyroid and Neck Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
  • Xiukun Hou
    Department of Thyroid and Neck Tumor, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, No. 1, Huanhu West Road, Tianjin, 300060, China.
  • Jingzhu Zhao
    Department of Thyroid and Neck Tumor, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, 300060, China.
  • Dapeng Li
    Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, PR China.
  • Songfeng Wei
    Department of Thyroid and Neck Tumor, Key Laboratory of Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, No. 1, Huanhu West Road, Tianjin, 300060, China. successor317@aliyun.com.
  • Xianhui Ruan
    Department of Thyroid and Neck Tumor, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
  • Xiangqian Zheng
    Department of Ultrasonography, Integrated Traditional Chinese and Western Medicine Hospital, Jilin, China.

Keywords

No keywords available for this article.