Current concepts in the pathogenesis and clinical management of lymphangioleiomyomatosis.

Journal: Current opinion in pulmonary medicine
Published Date: Jun 13, 2025

Abstract

PURPOSE OF REVIEW: Lymphangioleiomyomatosis (LAM) is a systemic, low-grade, metastasizing neoplasm that predominantly affects women. This review demonstrates recent progression in this rare disease, from improved understanding of pathogenesis, to novel treatments. We provide an overview of recent advances that are shaping the future of LAM diagnostic and treatment approaches.

Authors

  • Donal O'Malley
    Department of Respiratory Medicine, St. Vincent's University Hospital.
  • Nishant Gupta
    Department of Radiology, Columbia University Medical Center, 622 West 168th Street, PB-1-301, New York, NY, 10032, USA.
  • Cormac McCarthy
    Department of Respiratory Medicine, St. Vincent's University Hospital.

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