Adipose-Derived Mesenchymal Stem Cells Accelerate Diabetic Foot Ulcer Healing by Promoting Macrophage M2 Polarization Through Downregulation of and .

Journal: Journal of inflammation research
Published Date: Jun 12, 2025

Abstract

PURPOSE: Macrophage polarization plays a critical role in the chronic wound healing of diabetic foot ulcers (DFU). Recent studies have shown that adipose-derived mesenchymal stem cells (ADSCs) can reduce inflammation in DFU and promote wound healing. Despite advances in stem cell therapy, the molecular mechanisms by which ADSCs regulate macrophage polarization in DFU healing remain unclear, and robust prognostic models for DFU are lacking. This study aims to identify macrophage polarization-associated molecules in DFU and explore whether ADSCs promote DFU healing by regulating these molecules.

Authors

  • Jing Cao
    Eye Center, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Key Laboratory of Ophthalmology, Zhejiang Provincial Clinical Research Center for Eye Diseases, Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, Zhejiang, People's Republic of China.
  • Xin Zhang
    First Department of Infectious Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China.
  • Zhujun Li
    Department of Plastic Surgery, Peking Union Medical College Hospital, Beijing, People's Republic of China.
  • Sen Zhang
    Department of Gastrointestinal Surgery, Hernia Center, West China Hospital, Sichuan University, Chengdu, China.
  • Leiming Guo
    Research and Development Department, Beijing AegleStem Therapeutics Co., Ltd., Beijing, People's Republic of China.
  • Zichao Liu
    Research and Development Department, Beijing AegleStem Therapeutics Co., Ltd., Beijing, People's Republic of China.
  • Wenqiang An
    Research and Development Department, Beijing AegleStem Therapeutics Co., Ltd., Beijing, People's Republic of China.
  • Lijia Xu
    College of Mechanical and Electrical Engineering, Sichuan Agriculture University, Ya'an 625014, China.
  • Lijie Li
    College of Engineering, Swansea University, Bay Campus, Swansea SA1 8EN, UK. L.Li@swansea.ac.uk.
  • Xiao Long
    Department of Plastic and Aesthetic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
  • Yuemei Yang
    Research and Development Department, Beijing AegleStem Therapeutics Co., Ltd., Beijing, People's Republic of China.

Keywords

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