Simulation-free workflow for lattice radiation therapy using deep learning predicted synthetic computed tomography: A feasibility study.

Journal: Journal of applied clinical medical physics
Published Date: Jun 12, 2025

Abstract

PURPOSE: Lattice radiation therapy (LRT) is a form of spatially fractionated radiation therapy that allows increased total dose delivery aiming for improved treatment response without an increase in toxicities, commonly utilized for palliation of bulky tumors. The LRT treatment planning process is complex, while eligible patients often have an urgent need for expedited treatment start. In this study, we aimed to develop a simulation-free workflow for volumetric modulated arc therapy (VMAT)-based LRT planning via deep learning-predicted synthetic CT (sCT) to expedite treatment initiation.

Authors

  • Libing Zhu
    Mayo Clinic Arizona, Phoenix, AZ, United States.
  • Nathan Y Yu
    Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ (Y.H., J.H., S.H.P., N.Y.Y., W.L.); Cornell University, Ithaca, NY (Y.H.); Department of Electric Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA (Y.H.); and Department of Radiation Oncology, Mayo Clinic, Rochester, MN (A.B., E.L.M., D.K.E., D.M.R., S.S., C.L.H., B.E.B., M.W.).
  • Safia K Ahmed
    Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona, USA.
  • Jonathan B Ashman
    Department of Radiation Oncology, Mayo Clinic, Phoenix, Arizona, USA.
  • Diego Santos Toesca
    Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, Arizona, USA.
  • Michael P Grams
    Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
  • Christopher L Deufel
    Department of Radiation Oncology, Mayo Clinic, Rochester, USA.
  • Jingwei Duan
    Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky, USA.
  • Quan Chen
    Management School, Zhongshan Institute, University of Electronic Science and Technology of China, Guangdong, 528402, China.
  • Yi Rong
    Department of Radiation Oncology, University of California Davis Medical Center, Sacramento, CA, United States.

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