Dendritic cell dysfunction, including impaired IL-12 production, is associated with chronic pulmonary aspergillosis.

Journal: Clinical and experimental immunology
Published Date: Jun 12, 2025

Abstract

BACKGROUND: Growing evidence links immune dysfunction, notably impaired IFNγ production, to chronic pulmonary aspergillosis (CPA), but understanding of the immune phenotype in CPA patients remains limited.

Authors

  • Stefano A P Colombo
    Lydia Becker Institute of Immunology and Inflammation; Faculty of Biology, Medicine, and Health, The University of Manchester, Manchester, UK.
  • Sara Gago
    Manchester Fungal Infection Group; Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, UK.
  • Mathilde Chamula
    National Aspergillosis Centre; Manchester University NHS Foundation Trust, Manchester, UK.
  • Robert Lord
    Lydia Becker Institute of Immunology and Inflammation; Faculty of Biology, Medicine, and Health, The University of Manchester, Manchester, UK.
  • Andrew S MacDonald
    Lydia Becker Institute of Immunology and Inflammation; Faculty of Biology, Medicine, and Health, The University of Manchester, Manchester, UK.
  • Chris Kosmidis
    Manchester Fungal Infection Group; Faculty of Biology, Medicine, and Health, University of Manchester, Manchester, UK.

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