Fusion of FDG and FMZ PET Reduces False-Positives in Predicting Epileptogenic Zone.

Journal: AJNR. American journal of neuroradiology
Published Date: Jun 12, 2025

Abstract

BACKGROUND AND PURPOSE: Epilepsy, a globally prevalent neurologic disorder, necessitates precise identification of the epileptogenic zone (EZ) for effective surgical management. While the individual utilities of FDG-PET and flumazenil (FMZ)-PET have been demonstrated, their combined efficacy in localizing the epileptogenic zone remains underexplored. We aim to improve the noninvasive prediction of EZ in temporal lobe epilepsy (TLE) by combining FDG-PET and FMZ-PET with statistical feature extraction and machine learning.

Authors

  • Bingyang Cai
    From the National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, (B.C., H.H., J.L., S.Y., Y.C., J.L.), Shanghai Jiao Tong University, Shanghai, China.
  • Shize Jiang
    Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
  • Hui Huang
    Department of Biobank, The Sixth Affiliated People's Hospital of Dalian Medical University, Dalian, Liaoning, China.
  • Jiwei Li
  • Siyu Yuan
    From the National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy, School of Biomedical Engineering, (B.C., H.H., J.L., S.Y., Y.C., J.L.), Shanghai Jiao Tong University, Shanghai, China.
  • Ya Cui
    CAS Key Laboratory of Rna Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
  • Weiqi Bao
    PET Center (W.B.), Huashan Hospital, Fudan University, Shanghai, China.
  • Jie Hu
    Corteva Agriscience, Farming Solutions and Digital, Indianapolis, IN, United States.
  • Jie Luo
  • Liang Chen
    Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.

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