A Mortality Risk Prediction Model for Septic Shock in Patients Aged ≥50: Role of Norepinephrine Index and Procalcitonin.

Journal: International journal of general medicine
Published Date: Jun 10, 2025

Abstract

BACKGROUND: Septic shock is a high-mortality syndrome, particularly in patients aged 50 and older. Predicting mortality in this population is challenging due to clinical heterogeneity and limitations of traditional scoring systems like SOFA and APACHE II. This study aimed to develop and validate a predictive model using norepinephrine index (NEI)-a novel biomarker defined as the norepinephrine dose administered within the first 24 hours of ICU admission divided by BMI and 24 hours-and procalcitonin (PCT) to improve risk stratification and clinical decision-making.

Authors

  • Xue-Lin Li
    Department of Intensive Care Unit, Jining No. 1 People's Hospital, Shandong First Medical University, Jining, People's Republic of China.
  • Te Mi
    Department of Intensive Care Unit, Jining No. 1 Peoples' Hospital, Jining, 272011, Shandong, China.
  • Cancan Liu
    Department of Intensive Care Unit, Jining No. 1 People's Hospital, Shandong First Medical University, Jining, People's Republic of China.
  • Mingchen Feng
    Department of Intensive Care Unit, Jining No. 1 Peoples' Hospital, Jining, 272011, Shandong, China. sdjnfmch@163.com.

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