Identification of lipid metabolism-associated biomarkers in lupus nephritis by SVM model and therapeutic potential of Alisol B 23-acetate.

Journal: Gene
Published Date: Jun 10, 2025

Abstract

Systemic lupus erythematosus (SLE), a multifaceted autoimmune disorder, has lupus nephritis (LN) as one of its grave complications and is strongly associated with dyslipidemia. This investigation sought to delineate renal-specific lipid metabolism-related genes (LMRGs) signatures in lupus nephritis (LN) through integrated bioinformatics analysis and explore the therapeutic effect of Alisol B 23-acetate (ABA). Analysis of LN datasets revealed multiple dysregulated pathways and identified 11 key LMRGs, including CD36, associated with LN. In vitro, ABA suppressed CD36 activity, thereby reducing inflammation and lipid accumulation. In vivo, ABA improved lipid metabolism, attenuated immune cell infiltration, and ameliorated renal pathology. Renal lipid metabolic reprogramming exacerbates LN pathology, and ABA shows potential in treating LN by regulating key LMRGs.

Authors

  • Rong Li
    Department of Neurology, People's Hospital of Longhua, Shenzhen, China.
  • Jingqun Liu
    The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Yihong Gan
    The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Meng Jin
    Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening Biology Institute, Qilu University of Technology (Shandong Academy of Sciences) Jinan China.
  • Ke Lin
    Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
  • Yanzuo Wu
    The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Jinjun Ji
    School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, China.
  • Xinchang Wang
    The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Yongsheng Fan
    The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
  • Li Xu
    College of Acupuncture and Massage, Shandong University of Traditional Chinese Medicine, Jinan, China.

Keywords

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