Building Trust in Clinical AI: A Web-Based Explainable Decision Support System for Chronic Kidney Disease.

Journal: AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science
Published Date:

Abstract

Chronic Kidney Disease (CKD) is a significant global public health issue, affecting over 10% of the population. Timely diagnosis is crucial for effective management. Leveraging machine learning within healthcare offers promising advancements in predictive diagnostics. We developed a Web-Based Clinical Decision Support System (CDSS) for CKD, incorporating advanced Explainable AI (XAI) methods, specifically SHAP (Shapley Additive Explanations) and LIME (Local Interpretable Model-agnostic Explanations). The model employs and evaluates multiple classifiers: KNN, Random Forest, AdaBoost, XGBoost, CatBoost, and Extra Trees, to predict CKD. The effectiveness of the models is assessed by measuring their accuracy, analyzing confusion matrix statistics, and the AUC. AdaBoost achieved a 100% accuracy rate. Except for KNN, all classifiers consistently reached perfect precision and sensitivity. Additionally, we present a real-time web-based application to operationalize the model, enhancing trust and accessibility for healthcare practitioners and stakeholder.

Authors

  • Krishna Mridha
    Department of Population and Quantitative Health Sciences, Case Western Reserve University, School of Medicine, Cleveland, OH, USA.
  • Ming Wang
    Brain center, Zhejiang Hospital, Hangzhou, China.
  • Lijun Zhang
    Department of Paediatric Orthopaedics, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, China.

Keywords

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