Automated Diffusion Analysis for Non-Invasive Prediction of IDH Genotype in WHO Grade 2-3 Gliomas.

Journal: AJNR. American journal of neuroradiology
Published Date:

Abstract

BACKGROUND AND PURPOSE: Glioma molecular characterization is essential for risk stratification and treatment planning. Noninvasive imaging biomarkers such as apparent diffusion coefficient (ADC) values have shown potential for predicting glioma genotypes. However, manual segmentation of gliomas is time-consuming and operator-dependent. To address this limitation, we aimed to establish a single-sequence-derived automatic ADC extraction pipeline using T2-weighted imaging to support glioma isocitrate dehydrogenase (IDH) genotyping.

Authors

  • Jiaming Wu
    Centre for Medical Image Computing (CMIC), University College London, London, UK.
  • Stefanie C Thust
    National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, London, United Kingdom.
  • Stephen J Wastling
    From the Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK (JW, FPC, FB), Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK (JW, ST, SW, JM, FB), Radiological Sciences, Mental Health and Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK (ST), Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK (ST), NIHR Nottingham Biomedical Research Center, Nottingham, UK (ST), Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK (SW, GA, MB, JM, FB), Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, United Kingdom (GA), Department of Radiology, Mansoura University hospitals, Mansoura Faculty of Medicine, Egypt (GA), Department of Diagnostic Imaging and Radiotherapy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (MB), Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, UK (JM), Department of Neurodegenerative Disease, UCL Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London (SB), Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square MS Center, UCL Institute of Neurology, University College London, London, UK (FPC), e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain (FPC), Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands (FB).
  • Gehad Abdalla
    From the Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK (JW, FPC, FB), Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK (JW, ST, SW, JM, FB), Radiological Sciences, Mental Health and Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK (ST), Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK (ST), NIHR Nottingham Biomedical Research Center, Nottingham, UK (ST), Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK (SW, GA, MB, JM, FB), Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, United Kingdom (GA), Department of Radiology, Mansoura University hospitals, Mansoura Faculty of Medicine, Egypt (GA), Department of Diagnostic Imaging and Radiotherapy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (MB), Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, UK (JM), Department of Neurodegenerative Disease, UCL Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London (SB), Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square MS Center, UCL Institute of Neurology, University College London, London, UK (FPC), e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain (FPC), Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands (FB).
  • Massimo Benenati
    From the Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK (JW, FPC, FB), Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK (JW, ST, SW, JM, FB), Radiological Sciences, Mental Health and Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK (ST), Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK (ST), NIHR Nottingham Biomedical Research Center, Nottingham, UK (ST), Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK (SW, GA, MB, JM, FB), Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, United Kingdom (GA), Department of Radiology, Mansoura University hospitals, Mansoura Faculty of Medicine, Egypt (GA), Department of Diagnostic Imaging and Radiotherapy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (MB), Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, UK (JM), Department of Neurodegenerative Disease, UCL Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London (SB), Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square MS Center, UCL Institute of Neurology, University College London, London, UK (FPC), e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain (FPC), Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands (FB).
  • John A Maynard
    From the Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK (JW, FPC, FB), Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK (JW, ST, SW, JM, FB), Radiological Sciences, Mental Health and Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK (ST), Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK (ST), NIHR Nottingham Biomedical Research Center, Nottingham, UK (ST), Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK (SW, GA, MB, JM, FB), Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, United Kingdom (GA), Department of Radiology, Mansoura University hospitals, Mansoura Faculty of Medicine, Egypt (GA), Department of Diagnostic Imaging and Radiotherapy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (MB), Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, UK (JM), Department of Neurodegenerative Disease, UCL Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London (SB), Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square MS Center, UCL Institute of Neurology, University College London, London, UK (FPC), e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain (FPC), Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands (FB).
  • Sebastian Brandner
    Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London, UK.
  • Ferran Prados Carrasco
    From the Centre for Medical Image Computing (CMIC), Department of Medical Physics and Biomedical Engineering, University College London, London, UK (JW, FPC, FB), Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, UK (JW, ST, SW, JM, FB), Radiological Sciences, Mental Health and Neurosciences, School of Medicine, University of Nottingham, Nottingham, UK (ST), Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK (ST), NIHR Nottingham Biomedical Research Center, Nottingham, UK (ST), Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK (SW, GA, MB, JM, FB), Department of Neuroradiology, King's College Hospital NHS Foundation Trust, London, United Kingdom (GA), Department of Radiology, Mansoura University hospitals, Mansoura Faculty of Medicine, Egypt (GA), Department of Diagnostic Imaging and Radiotherapy, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy (MB), Department of Radiology, Guy's and St Thomas' NHS Foundation Trust, London, UK (JM), Department of Neurodegenerative Disease, UCL Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London NHS Foundation Trust, London (SB), Department of Neuroinflammation, Faculty of Brain Sciences, Queen Square MS Center, UCL Institute of Neurology, University College London, London, UK (FPC), e-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain (FPC), Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands (FB).
  • Frederik Barkhof
    MS Center Amsterdam, Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam Neuroscience, Amsterdam UMC location VUmc, the Netherlands.

Keywords

No keywords available for this article.