Use of natural language processing to identify inflammatory breast cancer cases across a healthcare system.

Journal: JNCI cancer spectrum
Published Date: Jun 10, 2025

Abstract

Early identification and referral of inflammatory breast cancer (IBC) remains challenging within large healthcare systems, limiting access to specialized care. We developed and evaluated an artificial intelligence-driven platform integrating natural language processing (NLP) with electronic health records to systematically identify potential IBC cases across five campuses. Our platform analyzed 8,623,494 clinical notes, implementing a sequential review process: NLP screening followed by human validation and multidisciplinary confirmation. Initial NLP screening achieved 55.4% positive predictive value, improving to 78.4% with human-in-the-loop review. Notably, among 255 confirmed IBC cases, our system demonstrated 92.2% sensitivity, identifying 57 cases (22.4%) that traditional surveillance methods missed. Documentation patterns significantly influenced system performance, with combined IBC and T4d staging mentions showing highest predictive value (98.2%). This proof-of-concept study demonstrates that lightweight NLP systems with targeted human review can identify rare cancer cases that may otherwise remain siloed within complex healthcare networks, ultimately improving access to specialized care resources.

Authors

  • Ramez Kouzy
    Department of Radiation Oncology, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Megumi Kai
    Department of Breast Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Huong T Le-Petross
    Department of Breast Imaging, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Sadia Saleem
    Department of Breast Medical Oncology, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Wendy A Woodward
    Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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