Uncovering Image-Driven Subtypes with Distinct Pathology and Clinical Course in Autopsy-Confirmed Four Repeat Tauopathies.

Journal: Annals of neurology
Published Date:

Abstract

OBJECTIVES: The four-repeat (4R) tauopathies are a group of neurodegenerative diseases, including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and globular glial tauopathy (GGT). This study aimed to characterize spatiotemporal atrophy progression using structural magnetic resonance imaging (MRI) and to examine its relationship with clinical course and neuropathology in a cohort of autopsy-confirmed 4R tauopathies.

Authors

  • Ryota Satoh
    Department of Radiology, Mayo Clinic, Rochester, MN.
  • Hiroaki Sekiya
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida.
  • Farwa Ali
    Department of Neurology, Mayo Clinic, Rochester, MN.
  • Heather M Clark
    Department of Neurology, Mayo Clinic, Rochester, MN.
  • Rene L Utianski
    Department of Neurology, Mayo Clinic, Rochester, MN.
  • Joseph R Duffy
    Department of Neurology, Mayo Clinic, Rochester, MN.
  • Mary M Machulda
    Mayo Clinic, Rochester MN, United States.
  • Dennis W Dickson
    From the Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
  • Keith A Josephs
    Department of Neurology, Mayo Clinic, Rochester, MN.
  • Jennifer L Whitwell
    Department of Radiology, Mayo Clinic, Rochester, MN.

Keywords

No keywords available for this article.