Non-invasive Assessment of Urinary Exfoliated Proximal Tubule Cell Multispectral Autofluorescence May Differentiate Between Causes of Kidney Transplant Dysfunction.

Journal: Kidney360
Published Date: Jun 20, 2025

Abstract

BACKGROUND: Complications relating to delayed or deteriorating graft function following kidney transplantation are common. There is no validated method apart from transplant kidney biopsy which can accurately identify between the histopathological causes of graft dysfunction. Considering an unmet critical need for a non-invasive approach to reliably diagnose kidney transplant complications, this work proposes a novel methodology based on the assessment of exfoliated proximal tubule cells (PTCs) extracted from urine of kidney transplant recipients by using their multispectral autofluorescence features.

Authors

  • Henry H L Wu
    Department of Renal Research, Kolling Institute of Medical Research, Royal North Shore Hospital & The University of Sydney, St. Leonards (Sydney) 2065, New South Wales, Australia.
  • Yandong Lang
    ARC Centre of Excellence for Nanoscale Biophotonics, School of Biomedical Engineering, The University of New South Wales, Sydney, Australia.
  • Shannon Handley
    ARC Centre of Excellence for Nanoscale Biophotonics, School of Biomedical Engineering, The University of New South Wales, Sydney, Australia.
  • Aline Knab
    ARC Centre of Excellence for Nanoscale Biophotonics, School of Biomedical Engineering, The University of New South Wales, Sydney, Australia.
  • Adnan Agha
    ARC Centre of Excellence for Nanoscale Biophotonics, School of Biomedical Engineering, The University of New South Wales, Sydney, Australia.
  • Yuan Tian
    Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
  • Akanksha Bhargava
    ARC Centre of Excellence for Nanoscale Biophotonics, School of Biomedical Engineering, The University of New South Wales, Sydney, Australia.
  • Ewa M Goldys
    ARC Centre of Excellence in Nanoscale Biophotonics (CNBP), Macquarie University , North Ryde 2109, Australia.
  • Carol A Pollock
    Renal Research Laboratory, Kolling Institute of Medical Research, Royal North Shore Hospital & The University of Sydney, Sydney, Australia.
  • Sonia Saad
    Renal Research Laboratory, Kolling Institute of Medical Research, Royal North Shore Hospital & The University of Sydney, Sydney, Australia.

Keywords

No keywords available for this article.

External Resources

Popular Topics
Recent Journals