Hub biomarkers and their clinical relevance in glycometabolic disorders: A comprehensive bioinformatics and machine learning approach.

Journal: Chinese medical journal
Published Date: Jun 20, 2025

Abstract

BACKGROUND: Gluconeogenesis is a critical metabolic pathway for maintaining glucose homeostasis, and its dysregulation can lead to glycometabolic disorders. This study aimed to identify hub biomarkers of these disorders to provide a theoretical foundation for enhancing diagnosis and treatment.

Authors

  • Liping Xiang
    Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
  • Bing Zhou
    Cooperative Innovation Center of Internet Healthcare, Zhengzhou University, Zhengzhou 450001, China.
  • Yunchen Luo
    Department of Endocrinology and Metabolism, Shanghai General Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200080, China.
  • Hanqi Bi
    Institute of Metabolism and Regenerative Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China.
  • Yan Lu
    National Institute of Standards and Technology.
  • Jian Zhou
    CTIQ, Canon Medical Research USA, Inc., Vernon Hills, 60061, USA.

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