Unravelling the multifaceted actions of neurosteroids: Machine learning and in vitro screening for novel target discovery.

Journal: British journal of pharmacology
Published Date: Jun 24, 2025

Abstract

BACKGROUND AND PURPOSE: Neurosteroids (NS) modulate neuronal function and are promising therapeutic agents for neuropsychiatric disorders. NS analogues are approved for treating postpartum depression and are of interest in other disorders. Gamma-aminobutyric acid type A (GABA) receptors are well characterised targets of natural NS, but other biological pathways are likely relevant to therapeutic mechanisms and/or to off-target effects.

Authors

  • Ajeet Kumar
    Department of Anaesthesiology, All India Institute of Medical Sciences, Patna, Bihar, India.
  • Mingxing Qian
    Department of Developmental Biology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
  • Yuanjian Xu
    Department of Developmental Biology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
  • Ann Benz
    Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
  • Douglas F Covey
    Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
  • Charles F Zorumski
    Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
  • Steven Mennerick
    Department of Psychiatry, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.

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