Association of peripheral immune markers with brain age and dementia risk estimated using deep learning methods.

Journal: International journal of surgery (London, England)
Published Date: Jun 25, 2025

Abstract

BACKGROUND: The peripheral immune system is essential for maintaining central nervous system homeostasis. This study investigates the effects of peripheral immune markers on accelerated brain aging and dementia using brain-predicted age difference based on neuroimaging.

Authors

  • Xiaxuan Huang
    Department of Neurology, The First Affiliated Hospital of Jinan University, No.613, Huangpu Road West, Guangzhou, Guangdong Province, 510630, China.
  • Shiqi Yuan
    Department of Neurology, The First Affiliated Hospital of Jinan University, No.613, Huangpu Road West, Guangzhou, Guangdong Province, 510630, China.
  • Yitong Ling
    Department of Neurology, The First Affiliated Hospital of Jinan University, No.613, Huangpu Road West, Guangzhou, Guangdong Province, 510630, China. lingyitong@stu2022.jnu.edu.cn.
  • Shanyuan Tan
    Department of Neurology, The First Affiliated Hospital of Jinan University, No.613, Huangpu Road West, Guangzhou, Guangdong Province, 510630, China.
  • Zihong Bai
    Department of Neurology, The First Affiliated Hospital of Jinan University, No.613, Huangpu Road West, Guangzhou, Guangdong Province, 510630, China.
  • Yixian Xu
    Department of Anesthesiology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
  • Si Shen
    Medical Imaging Center, The First Affiliated Hospital of Jinan University, Guangdong, China.
  • Jun Lyu
    Clinical Research Center, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, China.
  • Hao Wang
    Department of Cardiology, Second Medical Center, Chinese PLA General Hospital, Beijing, China.

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